Robert S Molday Selected Research

Retinoschisis (Retinoschisis, Juvenile)

1/2016	Cog-Wheel Octameric Structure of RS1, the Discoidin Domain Containing Retinal Protein Associated with X-Linked Retinoschisis.
5/2012	X-linked juvenile retinoschisis: clinical diagnosis, genetic analysis, and molecular mechanisms.
6/2009	In vivo imaging of the mouse model of X-linked juvenile retinoschisis with fourier domain optical coherence tomography.
1/2009	Relation of response to treatment with dorzolamide in X-linked retinoschisis to the mechanism of functional loss in retinoschisin.
9/2008	Characterization and purification of the discoidin domain-containing protein retinoschisin and its interaction with galactose.
11/2007	Retinoschisin (RS1), the protein encoded by the X-linked retinoschisis gene, is anchored to the surface of retinal photoreceptor and bipolar cells through its interactions with a Na/K ATPase-SARM1 complex.
6/2007	Coexpression and interaction of wild-type and missense RS1 mutants associated with X-linked retinoschisis: its relevance to gene therapy.
10/2005	Prolonged recovery of retinal structure/function after gene therapy in an Rs1h-deficient mouse model of x-linked juvenile retinoschisis.
3/2005	RS1, a discoidin domain-containing retinal cell adhesion protein associated with X-linked retinoschisis, exists as a novel disulfide-linked octamer.
7/2003	Defective discoidin domain structure, subunit assembly, and endoplasmic reticulum processing of retinoschisin are primary mechanisms responsible for X-linked retinoschisis.

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Robert S Molday Research Topics

Disease

15	Stargardt Disease 01/2022 - 12/2007
11	Retinoschisis (Retinoschisis, Juvenile) 01/2016 - 04/2002
9	Macular Degeneration (Age-Related Maculopathy) 01/2018 - 12/2004
7	Retinitis Pigmentosa (Pigmentary Retinopathy) 10/2015 - 08/2003
5	Retinal Degeneration 10/2015 - 01/2011
3	Retinal Diseases 01/2020 - 06/2007
3	Intellectual Disability (Idiocy) 12/2019 - 04/2014
3	Cerebellar Ataxia (Dysmetria) 12/2019 - 04/2014
3	Disease Progression 01/2019 - 06/2008
3	Vision Disorders (Hemeralopia) 10/2015 - 09/2008
3	Leber Congenital Amaurosis 01/2014 - 12/2010
2	Nervous System Diseases (Neurological Disorders) 12/2019 - 01/2019
2	Retinal Dystrophies 02/2015 - 02/2015
2	Leber Congenital Amaurosis 12 01/2014 - 10/2013
2	Tangier Disease 11/2013 - 09/2011
2	Cone-Rod Dystrophies 07/2009 - 02/2009
1	B-Cell Lymphoma (Lymphoma, B Cell) 01/2020
1	Anemia 01/2019
1	Congenital Hemolytic Anemia (Hemolytic Anemia, Congenital) 01/2019
1	Aniridia 01/2016
1	Ganglion Cysts (Ganglion) 01/2016
1	Blindness (Hysterical Blindness) 01/2016
1	congenital stationary Night blindness 10/2015
1	Dysequilibrium syndrome 04/2014
1	Inborn Genetic Diseases (Disease, Hereditary) 03/2013
1	Skin Diseases (Skin Disease) 09/2011
1	Lamellar Ichthyosis (Harlequin Ichthyosis) 09/2011
1	Ovarian Neoplasms (Ovarian Cancer) 01/2010
1	Neoplasms (Cancer) 01/2010
1	Cysts 01/2009

Drug/Important Bio-Agent (IBA)

23	Retinaldehyde (Retinal)IBA 11/2019 - 04/2002
17	Proteins (Proteins, Gene)FDA Link 11/2020 - 07/2003
9	ATP-Binding Cassette Transporters (ABC Transporters)IBA 01/2018 - 12/2007
4	RetinoidsIBA 01/2022 - 01/2010
4	LipidsIBA 01/2019 - 07/2009
4	Guanylate Cyclase (Guanylyl Cyclase)IBA 01/2014 - 12/2010
3	N-retinylidene-phosphatidylethanolamineIBA 11/2020 - 06/2012
3	Phospholipids (Phosphatides)FDA LinkGeneric 01/2019 - 09/2011
2	Adenosine Triphosphate (ATP)IBA 11/2020 - 10/2010
2	AntigensIBA 01/2020 - 01/2010
2	CholesterolIBA 11/2013 - 09/2011
2	phosphatidylethanolamineIBA 06/2012 - 07/2009
2	EnzymesIBA 10/2010 - 01/2010
2	DisulfidesIBA 03/2005 - 07/2003
1	LipofuscinIBA 01/2022
1	P-type ATPasesIBA 12/2019
1	Ion Pumps (Ion Pump)IBA 12/2019
1	Phospholipid Transfer ProteinsIBA 01/2019
1	PhosphatidylserinesIBA 01/2019
1	Adenosine Triphosphatases (ATPase)IBA 01/2019
1	CalciumIBA 10/2015
1	guanylate cyclase 1IBA 02/2015
1	Isoleucine (L-Isoleucine)FDA Link 04/2014
1	Oxidoreductases (Dehydrogenase)IBA 04/2014
1	Schiff Bases (Schiff Base)IBA 04/2014
1	Vitamin A (Retinol)FDA LinkGeneric 04/2014
1	HDL LipoproteinsIBA 11/2013
1	Carrier Proteins (Binding Protein)IBA 11/2011
1	SterolsIBA 09/2011
1	Surface-Active Agents (Surfactants)IBA 09/2011
1	Pulmonary Surfactants (Pulmonary Surfactant)IBA 09/2011
1	Phosphatidylcholines (Phosphatidylcholine)IBA 09/2011
1	Apolipoprotein A-I (Apolipoprotein A1)IBA 09/2011
1	Alanine (L-Alanine)FDA Link 08/2011
1	Retinal Pigments (Pigments, Visual)IBA 10/2010
1	Fatty Acids (Saturated Fatty Acids)IBA 10/2010
1	ImmunosorbentsIBA 01/2010
1	Biomarkers (Surrogate Marker)IBA 01/2010
1	Estrogens (Estrogen)FDA Link 01/2010
1	MucinsIBA 01/2010
1	Glycoproteins (Glycoprotein)IBA 01/2010
1	dorzolamide (Trusopt)FDA LinkGeneric 01/2009
1	Ophthalmic Solutions (Eye Drops)IBA 01/2009
1	CarbohydratesIBA 09/2008
1	Sepharose (Agarose)IBA 09/2008
1	RNA Precursors (Precursor, mRNA)IBA 05/2007
1	RNA Splicing FactorsIBA 05/2007
1	PeripherinsIBA 01/2004
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2004

Therapy/Procedure

2	Therapeutics 01/2016 - 06/2008
1	Precision Medicine 01/2020
1	Investigational Therapies (Experimental Therapy) 02/2015